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KMID : 1161420200230020161
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Journal of Medicinal Food
2020 Volume.23 No. 2 p.161 ~ p.172
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Effects of Phytosterol Ester on the Fatty Acid Profiles in Rats with Nonalcoholic Fatty Liver Disease
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Song Lihua
Zhou Haiyue
Yu Wenjuan
Ding Xinwen
Yang Li
Wu Jiayi
Song Chenwei
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Abstract
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Both serum and hepatic fatty acid (FA) compositions differ among nonalcoholic hepatic steatosis, nonalcoholic steatohepatitis, and healthy subjects. The severity of the above liver disease is closely associated with the concentration and composition of FAs. Our previous study found that phytosterol ester (PSE) could alleviate hepatic steatosis in nonalcoholic fatty liver disease rats. The aims of this work were to explore the effects of PSE (0.05/100?g·body weight) on FA profiles and the mRNA levels of FA metabolism-related genes. Compared with a high-fat diet alone group, PSE treatment significantly decreased hepatic saturated fatty acid levels (P?
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KEYWORD
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fatty acid profile, gene expression, nonalcoholic fatty liver disease, phytosterol ester
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